Protein Details: Potassium channel subfamily K member 3

Protein ID

ICDB_Pro_0183

Protein Name

Potassium channel subfamily K member 3

Gene Name

KCNK3; TASK; TASK1

Organism

Homo sapiens (Human)

Length

394 amino acids

AlphaFoldDB

AF-O14649-F1-model_v4.pdb

Function

pH-dependent;voltage-insensitive;background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high;current is inward.

Sequence

MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRARYNLSQGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSHYEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVYAEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGGGGRYSDTPSRRCLCSGAPRSAISSVSTGLHSLSTFRGLMKRRSSV

PDB Structures

6RV2 6RV3 6RV4

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Pulmonary Hypertension;Primary;4 and Pulmonary Hypertension;Primary;1

Location

Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain;lung;prostate;heart;kidney;uterus;small intestine and colon. Lower expression in brain;lung;prostate;heart;kidney;uterus;small intestine and colon. Lower expression in brain;lung;prostate;heart;kidney;uterus;small intestine and colon.

DOI ID

10.1093/emboj/16.17.5464; 10.1074/jbc.m001948200; 10.1038/nature03466; 10.1038/8084; 10.1007/s004240100620; 10.1126/scisignal.2003431; 10.1056/nejmoa1211097

RefSeq

NP_002237.1